NPR Top Stories

A trial was about to launch for a vaccine that would ward off the HIV virus. It would be an incredible breakthrough. Then it looked as if it would be over before it started.

The Administration for a Healthy America is RFK Jr.'s plan to tackle chronic disease, addiction and other persistent problems. But so far it's not being set up like previous new agencies.

Prediction market apps are thriving in Trump's second term, with traders betting on migrant deportations to election outcomes. A community of young, mostly male and very online traders are driving the industry's bonanza.

Minneapolis is at the center of sweeping, evolving federal immigration push. It demonstrates how different immigration enforcement is under Trump's second administration - and raises questions about the lingering effects on local communities and law enforcement.

Can't seem to match the energy of a good friend? You might be on opposite ends of the personality spectrum — and that's OK. Here's how to foster deep connections despite your differences.

The crew of USS Ford is struggling to handle sewage problems on board the Navy's newest carrier.

President Trump says he's cutting federal money to sanctuary cities. But courts have blocked similar moves, ruling that the federal government can't use funding to coerce state and local governments.

Officers in the Minneapolis-area participating in a U.S. immigration enforcement operation can't detain or tear gas peaceful protesters who aren't obstructing authorities, a judge ruled Friday.

Federal prosecutors are investigating Minnesota Gov. Tim Walz and Minneapolis Mayor Jacob Frey. In response to the news, Frey said in a social media post: "I will not be intimidated."

A Iran returns to an uneasy calm after protests led to a violent crackdown, a senior cleric is calling for the death penalty for detained demonstrators. His sermon Friday also threatened U.S. President Trump.